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抗体

TCR gamma/delta Monoclonal Antibody (eBioGL-3 (GL-3, GL3)), Super Bright 600, eBioscience™

63-5711-82

100微克

美国329.00

单克隆

仓鼠

Super Bright 600

eBioGL-3(GL-3, GL3)

TCR gamma/delta Monoclonal Antibody (eBioGL-3 (GL-3, GL3)), Super Bright 600, eBioscience™

63-5711-82

100微克

美国329.00

单克隆

亲和色谱

亚美尼亚仓鼠

小鼠

Flow Cytometry: 1.0 µg/test

小鼠

eBioGL-3(GL-3, GL3)

IgG

4° C, store in dark, DO NOT FREEZE!

TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

液体

Flow Cytometry: 1.0 µg/test

RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@