产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD206 (MMR) Monoclonal Antibody (19.2), PerCP-eFluor™ 710, eBioscience
目录 :
46-2069-41
规格 :
25试验
价格 :
美国146
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
Percp/efluor 710
克隆名称 :
19.2
反应物种 :
人类
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 13
参考文献 |
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产品信息
产品类型 :
抗体
产品名称 :
CD206 (MMR) Monoclonal Antibody (19.2), PerCP-eFluor™ 710, eBioscience
目录# :
46-2069-41
规格 :
25试验
定价 :
美国146
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 5 µL (0.06 µg)/test
物种 :
人类
克隆 :
19.2
抗体亚型 :
IgG1, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 5 µL (0.06 µg)/test
别名 :
AW259686; bA541I19.1; CD206; CELE_Y39A3CR.4; CLEC13D; CLEC13DL; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; ddp-1; hMR; Human mannose receptor; macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; Mitochondrial import inner membrane translocase subunit Tim8; MMR; MR; MRC1; MRC1L1; tim-8; Y39A3CR.4
更多信息或购买 :
公司信息
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赛默飞世尔
产品浏览
- CD206 (MMR) Monoclonal Antibody (19.2), PerCP-eFluor™ 710, eBioscience
- CD243 (ABCB1) Monoclonal Antibody (UIC2), PerCP-eFluor™ 710, eBioscience
- TCR V beta 5.1/5.2 Monoclonal Antibody (MR9-4), PerCP-eFluor™ 710, eBioscience
- TCR V beta 13 Monoclonal Antibody (MR12-3), PerCP-eFluor™ 710, eBioscience
- TCR V beta 12 Monoclonal Antibody (MR11-1), PerCP-eFluor™ 710, eBioscience
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