产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD117 (c-Kit) Monoclonal Antibody (ACK2), PerCP-eFluor™ 710, eBioscience
目录 :
46-1172-82
规格 :
100微克
价格 :
美国350
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
Percp/efluor 710
克隆名称 :
ACK2
反应物种 :
小鼠
应用 :
流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 12
参考文献
Gentle I, Moelter I, Badr M, D xf6 hner K, L xfc bbert M, H xe4 cker G. The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression. Cell Death Dis. 2021;12:675 pubmed 出版商
Naka K, Ochiai R, Matsubara E, Kondo C, Yang K, Hoshii T, et al. The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells. Nat Commun. 2020;11:4681 pubmed 出版商
Kwak M, Ninche N, Klein S, Saur D, Ghazizadeh S. c-Kit+ Cells in Adult Salivary Glands do not Function as Tissue Stem Cells. Sci Rep. 2018;8:14193 pubmed 出版商
Géraud C, Koch P, Zierow J, Klapproth K, Busch K, Olsavszky V, et al. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 2017;127:1099-1114 pubmed 出版商
Shirai C, White B, Tripathi M, Tapia R, Ley J, Ndonwi M, et al. Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. Nat Commun. 2017;8:14060 pubmed 出版商
Astuti Y, Kramer A, Blake A, Blazar B, Tolar J, Taisto M, et al. A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing. Stem Cell Reports. 2017;8:177-190 pubmed 出版商
Lai M, Gonzalez Martin A, Cooper A, Oda H, Jin H, Shepherd J, et al. Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs. Nat Commun. 2016;7:12207 pubmed 出版商
Puram R, Kowalczyk M, de Boer C, Schneider R, Miller P, McConkey M, et al. Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML. Cell. 2016;165:303-16 pubmed 出版商
Oh M, Oh S, Lu J, Lou H, Myers A, Zhu Z, et al. TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis. J Immunol. 2013;191:5371-82 pubmed 出版商
Schjerven H, McLaughlin J, Arenzana T, Frietze S, Cheng D, Wadsworth S, et al. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013;14:1073-83 pubmed 出版商
Carmona R, Cano E, Mattiotti A, Gaztambide J, Muñoz Chápuli R. Cells derived from the coelomic epithelium contribute to multiple gastrointestinal tissues in mouse embryos. PLoS ONE. 2013;8:e55890 pubmed 出版商
Czechowicz A, Kraft D, Weissman I, Bhattacharya D. Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science. 2007;318:1296-9 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD117 (c-Kit) Monoclonal Antibody (ACK2), PerCP-eFluor™ 710, eBioscience
目录# :
46-1172-82
规格 :
100微克
定价 :
美国350
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: 0.25 µg/test
物种 :
小鼠
克隆 :
ACK2
抗体亚型 :
IgG2b, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
c-Kit, also known as mast/stem cell growth factor receptor (SCFR) or CD117, is a trans membrane type III tyrosine kinase receptor encoded by the c-Kit proto-oncogene, located on chromosome 4 in humans. It is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.25 µg/test
别名 :
belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国