产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化JAK1(Tyr1022, Tyr1023)多克隆抗体
目录 :
44-422G
规格 :
100微升
价格 :
美国450
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 3
参考文献
Rautela J, Surgenor E, Huntington N. Drug target validation in primary human natural killer cells using CRISPR RNP. J Leukoc Biol. 2020;108:1397-1408 pubmed 出版商
Ghonim M, Wang J, Ibba S, Luu H, Pyakurel K, Benslimane I, et al. Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway. J Transl Med. 2018;16:243 pubmed 出版商
Zhang L, Xu L, Zhu J, Li J, Xue B, Gao J, et al. ATM‑JAK‑PD‑L1 signaling pathway inhibition decreases EMT and metastasis of androgen‑independent prostate cancer. Mol Med Rep. 2018;17:7045-7054 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
磷酸化JAK1(Tyr1022, Tyr1023)多克隆抗体
目录# :
44-422G
规格 :
100微升
价格 :
美国450
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠
应用 :
Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Western Blot: 1:1000
物种 :
人类, 小鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
免疫原 :
The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human JAK1 protein that contains tyrosines 1022 and 1023. The sequence is conserved in mouse and pig.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Western Blot: 1:1000
别名 :
AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; Jak1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国