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抗体

CD365 (TIM1) Monoclonal Antibody (1D12-TIM1), PE, eBioscience™

12-3659-41

25试验

美国135.00

单克隆

小鼠

PE

1D12-TIM1

CD365 (TIM1) Monoclonal Antibody (1D12-TIM1), PE, eBioscience™

12-3659-41

25试验

美国135.00

单克隆

亲和色谱

小鼠

人类

Flow Cytometry: 5 µL (0.125 µg)/test

人类

1D12-TIM1

IgG1, kappa

4° C, store in dark, DO NOT FREEZE!

CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4. In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes. Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity. CD365 has also been implicated in the T cell co-stimulation. CD365 is primarily expressed in epithelial cells. It is also highly expressed in A549, 769-P and Caco-2 and cell lines. CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.

IgV domain of human CD365

液体

Flow Cytometry: 5 µL (0.125 µg)/test

AI503787; CD365; HAVCR; Havcr1; HAVCR-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1