Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

抗体

[pSer282]Myosin-binding protein C (cardiac type) polyclonal antibody

ALX-215-057-R050

50微升

多克隆

domestic rabbit

未共轭

磷酸化

人类, 小鼠, 大鼠, 犬

免疫印迹, 免疫细胞化学

ALX-215-057-R050

[pSer282]Myosin-binding protein C (cardiac type) polyclonal antibody

兔

多克隆

磷酸化

抗体

50微升

26346517, 16894034

人类, 小鼠, 大鼠, 狗

Myosin-binding protein 2 (cardiac type) (cMyBP-C) is a protein located in the C-zones of the A-band of the sarcomere and interacts specifically with myosin, titin and actin. Mutations in the human cMyBP-C gene are one of the most frequent causes of familial hypertrophic cardiomyopathy. cMyBP-C can be phosphorylated at three different sites by a cAMP-regulated protein kinase (PKA) and a Ca2+<-calmodulin kinase (CAMK) bound to the thick filament. The dephosphorylated form binds to the S2 subfragment of myosin whereas the phosphorylated form binds to actin. In solution, phosphorylation of cMyBP-C increases force of contraction, but both phospho- and dephosphorylated forms of cMyBP-C stimulate the actin-activated myosin ATPase activity.

cMyBP-C, MYBPC3

Synthetic peptide corresponding to aa 276-288 (G276AGRRTpSDSHEDA288) of myosin-binding protein 2 (cardiac type) (cMyBP-C) phosphorylated at Ser282.

Recognizes cMyBP-C phosphorylated at Ser282.

液体。 在磷酸盐缓冲液, pH值7.4, 含0.1% BSA和0.01% 硫柳汞

Detects a band of ~150kDa by Western blot.

免疫细胞化学, 免疫印迹

-20°C