纤维连接蛋白, 细胞结合区域 | Developmental Studies Hybridoma Bank P1H11 产品信息

产品简要

公司名称 :

Developmental Studies Hybridoma Bank

产品类型 :

抗体

产品名称 :

纤维连接蛋白, 细胞结合区域

P1H11

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

P1H11

反应物种 :

人类, 小鼠, 大鼠

应用 :

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

文章摘录数: 7

参考文献
Saito D, Kyakumoto S, Chosa N, Ibi M, Takahashi N, Okubo N, et al. Transforming growth factor-?1 induces epithelial-mesenchymal transition and integrin ?3?1-mediated cell migration of HSC-4 human squamous cell carcinoma cells through Slug. J Biochem. 2013;153:303-15 pubmed 出版商
Yang J, Wang F, Tian L, Su J, Zhu X, Lin L, et al. Fibronectin and asialoglyprotein receptor mediate hepatitis B surface antigen binding to the cell surface. Arch Virol. 2010;155:881-8 pubmed 出版商
Arima Y, Inoue Y, Shibata T, Hayashi H, Nagano O, Saya H, et al. Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition. Cancer Res. 2008;68:5104-12 pubmed 出版商
Rojas R, Thomas J, Gehring A, Hill P, Belisle J, Harding C, et al. Phosphatidylinositol mannoside from Mycobacterium tuberculosis binds alpha5beta1 integrin (VLA-5) on CD4+ T cells and induces adhesion to fibronectin. J Immunol. 2006;177:2959-68 pubmed
Yu H, Frank D, Zhang J, You X, Carter W, Knudsen B. Basal prostate epithelial cells stimulate the migration of prostate cancer cells. Mol Carcinog. 2004;41:85-97 pubmed
Lampe P, Nguyen B, Gil S, Usui M, Olerud J, Takada Y, et al. Cellular interaction of integrin alpha3beta1 with laminin 5 promotes gap junctional communication. J Cell Biol. 1998;143:1735-47 pubmed
Carter W, Wayner E, Bouchard T, Kaur P. The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells. J Cell Biol. 1990;110:1387-404 pubmed

产品信息

内部号码 :

7930

名称 :

P1H11

Depositor Name :

Wayner, E.A.

Depositor Institution :

Fred Hutchison Cancer Research Center

Date Deposited :

10/11/11

Allow Hybridoma Distribution :

Yes

Cells Available (legacy) :

Yes

抗原 :

纤维连接蛋白, 细胞结合区域

抗原物种 :

人类

宿主物种 :

小鼠

抗体亚型 :

MIgG1

Isotype for catalog (legacy) :

IgG1

Positive Tested Species Reactivity :

人类, 小鼠, 灵长类动物, 大鼠

Species Tested (legacy) :

人类, 大鼠和灵长类动物

Initial Publication Pubmed ID :

1691191

Depositor Notes (Special Instructions) :

Frozen (acetone), paraformaldehyde, and methanol fixation work well for immunostaining. Doesn't appear to work for ELISA nor Flow cytometry. The MW observed by western blotting was 220 kDa (38 kDa and 190 kDa fibronectin A chain precursor). The epitope was mapped to the cell binding domain.

Collections :

Cell adhesion,Cell signaling,Extracellular matrix proteins,Human

搜索关键词 :

Wayner, E.A., fibronectin, cell binding domain, Human, MIgG1, Human/Rat/Primate/mouse, FN1, FN, CIG, FNZ, MSF, ED-B, FINC, GFND, LETS, GFND2, AB_2619588, monoclonal, Human/Cell adhesion/Extracellular matrix proteins/Cell signaling, Immunohistochemistry/Immunofluorescence/FFPE/Western Blot/Immunoprecipitation

抗原分子量 :

Predicted: multiple isoforms between 218 and 256 kDa and one or two isoforms at 69-71 kDa, plus shorter cleavage products.

基因 :

FN1

Alternate Gene Name(s) :

FN, CIG, FNZ, MSF, ED-B, FINC, GFND, LETS, GFND2

UniProt数据库编号 :

P02751

抗体登记处号码 :

AB_2619588

免疫原 :

纯化人类纤连蛋白

免疫原序列 :

全长蛋白

克隆性 :

单克隆

Myeloma Strain :

NS-1/狐狸-NY

表位定位 :

Yes

Epitope Location or Sequence :

Cell binding domain (aa 1267-1540 of isoform 1) [see Depositor Notes]

Recommended Applications :

FFPE, 免疫荧光, 免疫组化, 免疫沉淀, 免疫印迹

Immunoblotting (legacy) :

yes

免疫组化PubMed IDs :

1691191 9852164

免疫荧光PubMed IDs :

1691191

免疫印迹PubMed IDs :

18593909 23248240

免疫沉淀PubMed IDs :

15378647

其他信息 :

Acetone or paraformaldehyde fixation

DSHB增长培养基 :

RPMI

References (legacy) :

J. Cell Biol. 121(5), 1141-1152.; J. Immunol. 177, 2959-2968.; Hypertension 52, 910-917.; Cancer Res. 68(13), 5104-5112.; J. Card. Fail. 15(7), 616-628.Cancer Res. 70, 7810-7819.; Arch. Virol. 155(6), 881-888.

公司信息

Developmental Studies Hybridoma Bank

University of Iowa

dshb@uiowa.edu

http://dshb.biology.uiowa.edu

公司总部: 美国

Developmental Studies Hybridoma Bank (DSHB) 是NIH于1996年创办的国家机构，为生命科学研究领域及诊断领域，提供高质量的抗体等产品。

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