产品简要
公司名称 :
Developmental Studies Hybridoma Bank
产品类型 :
抗体
产品名称 :
整合素αⅤ乙5(CD51, 纤连蛋白/玻璃粘连蛋白受体)
目录 :
P1F6
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
P1F6
反应物种 :
人类, 大鼠, 鸡
应用 :
酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 流式细胞仪
更多信息或购买 :
Developmental Studies Hybridoma Bank 产品网页
文章摘录数: 13
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 1a
  • 免疫沉淀; 人类; 图 1b
Beauvais D, Jung O, Yang Y, Sanderson R, Rapraeger A. Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth. Cancer Res. 2016;76:4981-93 pubmed 出版商
Buchholz D, Hikita S, Rowland T, Friedrich A, Hinman C, Johnson L, et al. Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells. Stem Cells. 2009;27:2427-34 pubmed 出版商
Scotton C, Krupiczojc M, Konigshoff M, Mercer P, Lee Y, Kaminski N, et al. Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest. 2009;119:2550-63 pubmed 出版商
Wipff P, Rifkin D, Meister J, Hinz B. Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol. 2007;179:1311-23 pubmed
Wang H, Kandel R. Chondrocytes attach to hyaline or calcified cartilage and bone. Osteoarthritis Cartilage. 2004;12:56-64 pubmed
Akakura S, Singh S, Spataro M, Akakura R, Kim J, Albert M, et al. The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells. Exp Cell Res. 2004;292:403-16 pubmed
Pedchenko V, Zent R, Hudson B. Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesion. J Biol Chem. 2004;279:2772-80 pubmed
Zhou Q, Nakada M, Brooks P, Swenson S, Ritter M, Argounova S, et al. Contortrostatin, a homodimeric disintegrin, binds to integrin alphavbeta5. Biochem Biophys Res Commun. 2000;267:350-5 pubmed
Memmo L, McKeown Longo P. The alphavbeta5 integrin functions as an endocytic receptor for vitronectin. J Cell Sci. 1998;111 ( Pt 4):425-33 pubmed
Aplin J, Spanswick C, Behzad F, Kimber S, Vicovac L. Integrins beta 5, beta 3 and alpha v are apically distributed in endometrial epithelium. Mol Hum Reprod. 1996;2:527-34 pubmed
De Nichilo M, Yamada K. Integrin alpha v beta 5-dependent serine phosphorylation of paxillin in cultured human macrophages adherent to vitronectin. J Biol Chem. 1996;271:11016-22 pubmed
Weinacker A, Chen A, Agrez M, Cone R, Nishimura S, Wayner E, et al. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem. 1994;269:6940-8 pubmed
Wayner E, Orlando R, Cheresh D. Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface. J Cell Biol. 1991;113:919-29 pubmed
产品信息
内部号码 :
7934
名称 :
P1F6
Depositor Name :
Wayner, E.A.
Depositor Institution :
Fred Hutchison Cancer Research Center
Date Deposited :
10/11/11
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
抗原 :
整合素αⅤ乙5(CD51, 纤连蛋白/玻璃粘连蛋白受体)
抗原物种 :
人类
宿主物种 :
小鼠
抗体亚型 :
MIgG1
Isotype for catalog (legacy) :
IgG1
Positive Tested Species Reactivity :
鸡, 仓鼠, 人类, 大鼠
Species Tested (legacy) :
人类, 大鼠和鸡
Initial Publication Pubmed ID :
1709170
Depositor Notes (Special Instructions) :
Immunostaining works only on acetone fixed preps. P1F6 completely inhibits alphaVbeta5 dependent binding to vitronectin-coated substrates. Doesn't cross-reactwith alphaVbeta3.
Collections :
CD抗原, 细胞粘附, 人类
搜索关键词 :
Wayner, E.A., integrin alpha V beta 5 (CD51, fibronectin/vitronectin receptor), Human, MIgG1, Human/Rat/Chicken/Hmaster, ITGAV/ITGB5, , AB_2619586, monoclonal, Cell adhesion/Cluster Determinant antigens/Human, Immunohistochemistry/Immunofluorescence/Immunoprecipitation/Function Blocking/ELISA/FACS
抗原分子量 :
Apparent: 160 kDa (alpha chain), 95 kDa (beta chain)
基因 :
ITGAV/ITGB5
UniProt数据库编号 :
P06756 P18084
抗体登记处号码 :
AB_2619586
Synonyms (Alternate Clone Names) :
CD49e, CD51
免疫原 :
small cell lung carcinoma from the UCLA P3 cell line expressing the vitronectin receptor.
免疫原序列 :
全长蛋白
克隆性 :
单克隆
Myeloma Strain :
NS-1/狐狸-NY
表位定位 :
No
Recommended Applications :
ELISA,FACS,Function Blocking,Immunofluorescence,Immunohistochemistry,Immunoprecipitation
Immunoblotting (legacy) :
no
免疫组化PubMed IDs :
19652365
免疫荧光PubMed IDs :
18086923 9443892
免疫沉淀PubMed IDs :
8120056 14610079
Function Blocking Pubmed IDs :
1709170 8120056 19658190 19652365 10623623 14697683 8631923
流式细胞仪PubMed IDs :
8120056 10623623 14697347 8631923
PubMed IDs :
9239663
其他信息 :
P1F6 recognizes a composite epitope on alphaV/beta5 native heterodimer integrin.
DSHB增长培养基 :
RPMI
References (legacy) :
J. Cell Biol. 133(4), 919-929.; J. Biol. Chem. 269(9), 6940-6948.; Mol. Hum. Reprod. 2, 527-534.; Biochem. Biophys. Res. Commun. 267(1), 350-355.; J. Cell Biol. 179(6), 1311-1323.; Stem Cells 27(10), 2427-2434.; J. Clin. Invest. 119(9), 2550-2563.
更多信息或购买 :
Developmental Studies Hybridoma Bank 产品网页
公司信息
Developmental Studies Hybridoma Bank
University of Iowa
dshb@uiowa.edu
http://dshb.biology.uiowa.edu
公司总部: 美国
Developmental Studies Hybridoma Bank (DSHB) 是NIH于1996年创办的国家机构，为生命科学研究领域及诊断领域，提供高质量的抗体等产品。