| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
| Escasany E, Lanzón B, García Carrasco A, Izquierdo Lahuerta A, Torres L, Corrales P, et al. Transforming growth factor β3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney. Dis Model Mech. 2021;14: pubmed 出版商 |
| Mou S, Zhou Z, Feng H, Zhang N, Lin Z, Aiyasiding X, et al. Liquiritin Attenuates Lipopolysaccharides-Induced Cardiomyocyte Injury via an AMP-Activated Protein Kinase-Dependent Signaling Pathway. Front Pharmacol. 2021;12:648688 pubmed 出版商 |
| Watahiki A, Hoshikawa S, Chiba M, Egusa H, Fukumoto S, Inuzuka H. Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages. Int J Mol Sci. 2021;22: pubmed 出版商 |
| Fujiwara Y, Ohnishi K, Horlad H, Saito Y, Shiraishi D, Takeya H, et al. CD163 deficiency facilitates lipopolysaccharide-induced inflammatory responses and endotoxin shock in mice. Clin Transl Immunology. 2020;9:e1162 pubmed 出版商 |
| Jiang L, Xu K, Li J, Zhou X, Xu L, Wu Z, et al. Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. Aging (Albany NY). 2020;12:1760-1777 pubmed 出版商 |
| Buhl E, Djudjaj S, Klinkhammer B, Ermert K, Puelles V, Lindenmeyer M, et al. Dysregulated mesenchymal PDGFR-β drives kidney fibrosis. EMBO Mol Med. 2020;12:e11021 pubmed 出版商 |
| Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, et al. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol. 2020;21:30-41 pubmed 出版商 |
| Veschi V, Mangiapane L, Nicotra A, Di Franco S, Scavo E, Apuzzo T, et al. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant. Oncogene. 2020;39:987-1003 pubmed 出版商 |
| Huang X, Ni B, Xi Y, Chu X, Zhang R, You H. Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis. Aging (Albany NY). 2019;11:12532-12545 pubmed 出版商 |
| Lin F, Meng X, Guo Y, Cao W, Liu W, Xia Q, et al. Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. Sci Adv. 2019;5:eaax1608 pubmed 出版商 |
| Majer O, Liu B, Kreuk L, Krogan N, Barton G. UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity. Nature. 2019;575:366-370 pubmed 出版商 |
| Zierhut C, Yamaguchi N, Paredes M, Luo J, Carroll T, Funabiki H. The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death. Cell. 2019;178:302-315.e23 pubmed 出版商 |
| Dumont A, de Rosny C, Kieu T, Perrey S, Berger H, Fluckiger A, et al. Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment. Cell Death Dis. 2019;10:485 pubmed 出版商 |
| Guo M, Hartlova A, Gierlinski M, Prescott A, Castellvi J, Losa J, et al. Triggering MSR1 promotes JNK-mediated inflammation in IL-4-activated macrophages. EMBO J. 2019;38: pubmed 出版商 |
| Kennedy S, Han J, Portman N, Nobis M, Hastings J, Murphy K, et al. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer. Breast Cancer Res. 2019;21:43 pubmed 出版商 |
- 免疫组化-石蜡切片; 大鼠; 1:250; 图 s3f, s3n
- 免疫印迹; 大鼠; 图 s1c
| Mammone T, Chidlow G, Casson R, Wood J. Improved immunohistochemical detection of phosphorylated mitogen-activated protein kinases in the injured rat optic nerve head. Histochem Cell Biol. 2019;151:435-456 pubmed 出版商 |
| Smith B, Wang S, Jaime Figueroa S, Harbin A, Wang J, Hamman B, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019;10:131 pubmed 出版商 |
| Cao Y, Xu Y, Auchoybur M, Chen W, He S, Qin W, et al. Regulatory role of IKKɑ in myocardial ischemia/reperfusion injury by the determination of M1 versus M2 polarization of macrophages. J Mol Cell Cardiol. 2018;123:1-12 pubmed 出版商 |
| Yan M, Ye L, Yin S, Lu X, Liu X, Lu S, et al. Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy. Br J Pharmacol. 2018;175:3747-3757 pubmed 出版商 |
| Shen Q, Zhang Q, Shi Y, Shi Q, Jiang Y, Gu Y, et al. Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation. Nature. 2018;554:123-127 pubmed 出版商 |
| Park G, Kim D. Cigarette smoke-induced EGFR activation promotes epithelial mesenchymal migration of human retinal pigment epithelial cells through regulation of the FAK-mediated Syk/Src pathway. Mol Med Rep. 2018;17:3563-3574 pubmed 出版商 |
| Zhong J, Wang H, Chen W, Sun Z, Chen J, Xu Y, et al. Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways. Cell Death Dis. 2017;8:e2763 pubmed 出版商 |
| Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, et al. Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. J Clin Invest. 2017;127:2235-2248 pubmed 出版商 |
| Kim D, Ko H, Park G, Hur D, Kim Y, Yang J. Vandetanib and ADAM inhibitors synergistically attenuate the pathological migration of EBV-infected retinal pigment epithelial cells by regulating the VEGF-mediated MAPK pathway. Exp Ther Med. 2017;13:1415-1425 pubmed 出版商 |
| Strickson S, Emmerich C, Goh E, Zhang J, Kelsall I, MacArtney T, et al. Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc Natl Acad Sci U S A. 2017;114:E3481-E3489 pubmed 出版商 |
| Du M, Martin A, HAYS F, Johnson J, FARJO R, Farjo K. Serum retinol-binding protein-induced endothelial inflammation is mediated through the activation of toll-like receptor 4. Mol Vis. 2017;23:185-197 pubmed |
| Bittner S, Knoll G, Ehrenschwender M. Death receptor 3 signaling enhances proliferation of human regulatory T cells. FEBS Lett. 2017;591:1187-1195 pubmed 出版商 |
- 免疫印迹; 小鼠; 图 EV3d
- 免疫印迹; 人类; 图 7a
| Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed 出版商 |
| Shin S, Song J, Hwang B, Noh D, Park S, Kim W, et al. HSPA6 augments garlic extract-induced inhibition of proliferation, migration, and invasion of bladder cancer EJ cells; Implication for cell cycle dysregulation, signaling pathway alteration, and transcription factor-associated MMP-9 regulation. PLoS ONE. 2017;12:e0171860 pubmed 出版商 |
| Xiong X, Liu Y, Mei Y, Peng J, Wang Z, Kong B, et al. Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling. Sci Rep. 2017;7:41857 pubmed 出版商 |
| Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P. Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon ?. Biochem J. 2017;474:1163-1174 pubmed 出版商 |
| Wu M, Chen W, Lu Y, Zhu G, Hao L, Li Y. Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway. Nat Commun. 2017;8:13700 pubmed 出版商 |
| Chen G, Chen J, Yan Z, Li Z, Yu M, Guo W, et al. Maternal diabetes modulates dental epithelial stem cells proliferation and self-renewal in offspring through apurinic/apyrimidinicendonuclease 1-mediated DNA methylation. Sci Rep. 2017;7:40762 pubmed 出版商 |
| Newton K, Wickliffe K, Maltzman A, Dugger D, Strasser A, Pham V, et al. RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. 2016;540:129-133 pubmed 出版商 |
| Ulbrich F, Kaufmann K, Meske A, Lagrèze W, Augustynik M, Buerkle H, et al. The CORM ALF-186 Mediates Anti-Apoptotic Signaling via an Activation of the p38 MAPK after Ischemia and Reperfusion Injury in Retinal Ganglion Cells. PLoS ONE. 2016;11:e0165182 pubmed 出版商 |
| Lu W, Shi J, Zhang J, Lv Z, Guo F, Huang H, et al. CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model. Int J Mol Sci. 2016;17: pubmed |
| Wang C, Zhang F, Cao Y, Zhang M, Wang A, Xu M, et al. Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress. Sci Rep. 2016;6:34330 pubmed 出版商 |
| Shi Y, Yu Y, Wang Z, Wang H, Bieerkehazhi S, Zhao Y, et al. Second-generation proteasome inhibitor carfilzomib enhances doxorubicin-induced cytotoxicity and apoptosis in breast cancer cells. Oncotarget. 2016;7:73697-73710 pubmed 出版商 |
| Zhang K, Cai H, Gao S, Yang G, Deng H, Xu G, et al. TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals. Oncotarget. 2016;7:69436-69449 pubmed 出版商 |
| Ji M, Lu Y, Zhao C, Gao W, He F, Zhang J, et al. C5a Induces the Synthesis of IL-6 and TNF-? in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways. PLoS ONE. 2016;11:e0161867 pubmed 出版商 |
| Ruess D, Probst M, Marjanovic G, Wittel U, Hopt U, Keck T, et al. HDACi Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA) Delay but Fail to Protect against Warm Hepatic Ischemia-Reperfusion Injury. PLoS ONE. 2016;11:e0161233 pubmed 出版商 |
| Tsai S, Rodriguez A, Dastidar S, Del Greco E, Carr K, Sitzmann J, et al. Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice. Cell Rep. 2016;16:1903-14 pubmed 出版商 |
| Raguz J, Jerić I, Niault T, Nowacka J, Kuzet S, Rupp C, et al. Epidermal RAF prevents allergic skin disease. elife. 2016;5: pubmed 出版商 |
| Subramaniam S, Ozdener M, Abdoul Azize S, Saito K, Malik B, Maquart G, et al. ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J. 2016;30:3489-3500 pubmed |
| Kuramoto K, Wang N, Fan Y, Zhang W, Schoenen F, Frankowski K, et al. Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids. Autophagy. 2016;12:1460-71 pubmed 出版商 |
| Liu L, Lv G, Ning C, Yang Y, Zhu J. Therapeutic effects of 1,25-dihydroxyvitamin D3 on diabetes-induced liver complications in a rat model. Exp Ther Med. 2016;11:2284-2292 pubmed |
| Shutinoski B, Alturki N, Rijal D, Bertin J, Gough P, Schlossmacher M, et al. K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death Differ. 2016;23:1628-37 pubmed 出版商 |
| Leonard S, Kinsella G, Benetti E, Findlay J. Regulating the effects of GPR21, a novel target for type 2 diabetes. Sci Rep. 2016;6:27002 pubmed 出版商 |
| Yu Z, Chen T, Li X, Yang M, Tang S, Zhu X, et al. Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. elife. 2016;5: pubmed 出版商 |
| Su K, Cao J, Tang Z, Dai S, He Y, Sampson S, et al. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016;18:527-39 pubmed 出版商 |
| Naik E, Dixit V. Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity. J Immunol. 2016;196:3438-51 pubmed 出版商 |
| Yu C, Tang L, Liang C, Chen X, Song S, Ding X, et al. Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure Overload-Induced Cardiac Hypertrophy. J Am Heart Assoc. 2016;5: pubmed 出版商 |
| Kim D, Helfman D. Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling. Oncogene. 2016;35:4495-508 pubmed 出版商 |
| Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016;11:182-188 pubmed |
| Lancaster G, Kammoun H, Kraakman M, Kowalski G, Bruce C, Febbraio M. PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications. Nat Commun. 2016;7:10626 pubmed 出版商 |
| Wu X, Yang L, Zheng Z, Li Z, Shi J, Li Y, et al. Src promotes cutaneous wound healing by regulating MMP-2 through the ERK pathway. Int J Mol Med. 2016;37:639-48 pubmed 出版商 |
| Ito T, Itakura J, Takahashi S, Sato M, Mino M, Fushimi S, et al. Sprouty-Related Ena/Vasodilator-Stimulated Phosphoprotein Homology 1-Domain-Containing Protein-2 Critically Regulates Influenza A Virus-Induced Pneumonia. Crit Care Med. 2016;44:e530-43 pubmed 出版商 |
| Chen P, Li J, Huo Y, Lu J, Wan L, Li B, et al. Orphan nuclear receptor NR4A2 inhibits hepatic stellate cell proliferation through MAPK pathway in liver fibrosis. Peerj. 2015;3:e1518 pubmed 出版商 |
| Roth Flach R, Skoura A, Matevossian A, Danai L, Zheng W, Cortes C, et al. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015;6:8995 pubmed 出版商 |
| Wu Y, Ai X, Liu F, Liang H, Zhang B, Chen X. c-Jun N-terminal kinase inhibitor favors transforming growth factor-β to antagonize hepatitis B virus X protein-induced cell growth promotion in hepatocellular carcinoma. Mol Med Rep. 2016;13:1345-52 pubmed 出版商 |
| Ni Y, Nagashimada M, Zhuge F, Zhan L, Nagata N, Tsutsui A, et al. Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E. Sci Rep. 2015;5:17192 pubmed 出版商 |
| Awad K, Elinoff J, Wang S, Gairhe S, Ferreyra G, Cai R, et al. Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2016;310:L187-201 pubmed 出版商 |
| Wang Y, Zhang Y, Hu W, Xie S, Gong C, Iqbal K, et al. Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation. Sci Rep. 2015;5:15709 pubmed 出版商 |
| Dumas A, Lê Bury G, Marie Anaïs F, Herit F, Mazzolini J, Guilbert T, et al. The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking. J Cell Biol. 2015;211:359-72 pubmed 出版商 |
| Gruosso T, Garnier C, Abélanet S, Kieffer Y, Lemesre V, Bellanger D, et al. MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas. Nat Commun. 2015;6:8583 pubmed 出版商 |
| Zhou X, Tao Y, Liang C, Zhang Y, Li H, Chen Q. BMP3 Alone and Together with TGF-β Promote the Differentiation of Human Mesenchymal Stem Cells into a Nucleus Pulposus-Like Phenotype. Int J Mol Sci. 2015;16:20344-59 pubmed 出版商 |
| Yan G, Wang Q, Hu S, Wang D, Qiao Y, Ma G, et al. Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury. Int J Mol Med. 2015;36:1001-11 pubmed 出版商 |
| Moreau K, Ghislat G, Hochfeld W, Renna M, Zavodszky E, Runwal G, et al. Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy. Nat Commun. 2015;6:8045 pubmed 出版商 |
| Simard E, Söllradl T, Maltais J, Boucher J, D Orléans Juste P, Grandbois M. Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function. PLoS ONE. 2015;10:e0128881 pubmed 出版商 |
| Zhang X, Wang X, Wu T, Li B, Liu T, Wang R, et al. Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation. Sci Rep. 2015;5:12579 pubmed 出版商 |
| Wu P, Yen J, Kou M, Wu M. Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. PLoS ONE. 2015;10:e0130599 pubmed 出版商 |
| Unni A, Lockwood W, Zejnullahu K, Lee Lin S, Varmus H. Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. elife. 2015;4:e06907 pubmed 出版商 |
| Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed 出版商 |
| Suzuki M, Takeda T, Nakagawa H, Iwata S, Watanabe T, Siddiquey M, et al. The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas. Front Microbiol. 2015;6:280 pubmed 出版商 |
| Ko R, Park J, Ha H, Choi Y, Lee S. Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production. Nat Commun. 2015;6:6765 pubmed 出版商 |
- 免疫印迹; 小鼠; 1:1000; 图 6
- 免疫印迹; 人类; 1:1000; 图 2
| Yang Y, Deng Q, Feng X, Sun J. Use of the disulfiram/copper complex for breast cancer chemoprevention in MMTV-erbB2 transgenic mice. Mol Med Rep. 2015;12:746-52 pubmed 出版商 |
| Lee J, Chung L, Chen Y, Feng T, Chen W, Juang H. Upregulation of B-cell translocation gene 2 by epigallocatechin-3-gallate via p38 and ERK signaling blocks cell proliferation in human oral squamous cell carcinoma cells. Cancer Lett. 2015;360:310-8 pubmed 出版商 |
| Santhana Kumar K, Tripolitsioti D, Ma M, Grählert J, Egli K, Fiaschetti G, et al. The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma. Springerplus. 2015;4:19 pubmed 出版商 |
| Yoo J, Kim T, Kong S, Lee J, Choi W, Kim K, et al. Role of Mig-6 in hepatic glucose metabolism. J Diabetes. 2016;8:86-97 pubmed 出版商 |
| Pajaud J, Ribault C, Ben Mosbah I, Rauch C, Henderson C, Bellaud P, et al. Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration. Cell Death Dis. 2015;6:e1598 pubmed 出版商 |
| Blanchard Z, Paul B, Craft B, ElShamy W. BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers. Breast Cancer Res. 2015;17:5 pubmed 出版商 |
| Chuang C, Guh J, Lu C, Chen H, Chuang L. S100B is required for high glucose-induced pro-fibrotic gene expression and hypertrophy in mesangial cells. Int J Mol Med. 2015;35:546-52 pubmed 出版商 |
| O Connell K, Guo W, Serra C, Beck M, Wachtman L, Hoggatt A, et al. The effects of an ActRIIb receptor Fc fusion protein ligand trap in juvenile simian immunodeficiency virus-infected rhesus macaques. FASEB J. 2015;29:1165-75 pubmed 出版商 |
| Wang Y, Xiao X, Li N, Yang D, Xing Y, Huo R, et al. Oestrogen inhibits BMP4-induced BMP4 expression in cardiomyocytes: a potential mechanism of oestrogen-mediated protection against cardiac hypertrophy. Br J Pharmacol. 2015;172:5586-95 pubmed 出版商 |
| Huang S, Lee C, Wang H, Chang Y, Lin C, Chen C, et al. 6-Dehydrogingerdione restrains lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages. J Agric Food Chem. 2014;62:9171-9 pubmed 出版商 |
| Yu B, Chang J, Liu Y, Li J, Kevork K, Al Hezaimi K, et al. Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-?B. Nat Med. 2014;20:1009-17 pubmed 出版商 |
| Zhang S, Ren M, Zeng X, He P, Ma X, Qiao S. Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC-J2) through PI3K/Akt/mTOR and ERK signaling pathways. Amino Acids. 2014;46:2633-42 pubmed 出版商 |
| Singel S, Batten K, Cornelius C, Jia G, Fasciani G, Barron S, et al. Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways. Breast Cancer Res. 2014;16:R28 pubmed 出版商 |
| Ma M, Baumgartner M. Intracellular Theileria annulata promote invasive cell motility through kinase regulation of the host actin cytoskeleton. PLoS Pathog. 2014;10:e1004003 pubmed 出版商 |
| Jamal S, Cheriyan V, Muthu M, Munie S, Levi E, Ashour A, et al. CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells. PLoS ONE. 2014;9:e89146 pubmed 出版商 |
| Zhang Y, Zhang X, Gao L, Liu Y, Jiang D, Chen K, et al. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Biochim Biophys Acta. 2014;1842:232-44 pubmed 出版商 |
| Kim T, Kang Y, Park Z, Kim Y, Hong S, Oh S, et al. SH3RF2 functions as an oncogene by mediating PAK4 protein stability. Carcinogenesis. 2014;35:624-34 pubmed 出版商 |
| Lee J, Park J, Kwon O, Kim H, Fornace A, Cha H. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. J Dermatol Sci. 2014;73:125-34 pubmed 出版商 |
| Lemire B, Debigare R, Dubé A, Thériault M, Cote C, Maltais F. MAPK signaling in the quadriceps of patients with chronic obstructive pulmonary disease. J Appl Physiol (1985). 2012;113:159-66 pubmed 出版商 |
| Ebelt N, Kaoud T, Edupuganti R, Van Ravenstein S, Dalby K, Van Den Berg C. A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib. Oncotarget. 2017;8:104894-104912 pubmed 出版商 |
| Perdiz D, Lorin S, Leroy Gori I, Poüs C. Stress-induced hyperacetylation of microtubule enhances mitochondrial fission and modulates the phosphorylation of Drp1 at 616Ser. Cell Signal. 2017;39:32-43 pubmed 出版商 |
| Liao X, Feng B, Zhang D, Liu P, Zhou X, Li R, et al. The Sirt6 gene: Does it play a role in tooth development?. PLoS ONE. 2017;12:e0174255 pubmed 出版商 |
| Yang N, Shi J, Wu F, Li M, Zhang X, Li Y, et al. Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediated mitogen activated protein kinases pathway. World J Gastroenterol. 2017;23:1203-1214 pubmed 出版商 |
| Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, et al. γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis. Sci Rep. 2016;6:35930 pubmed 出版商 |
| Ding H, Wu P, Wu M. Cleome rutidosperma and Euphorbia thymifolia Suppress Inflammatory Response via Upregulation of Phase II Enzymes and Modulation of NF-?B and JNK Activation in LPS-Stimulated BV2 Microglia. Int J Mol Sci. 2016;17: pubmed 出版商 |
| Joseph J, Ametepe E, Haribabu N, Agbayani G, Krishnan L, Blais A, et al. Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium. Nat Commun. 2016;7:12748 pubmed 出版商 |
| Dyshlovoy S, Tabakmakher K, Hauschild J, Shchekaleva R, Otte K, Guzii A, et al. Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro. Mar Drugs. 2016;14: pubmed 出版商 |
| Shi Y, Huang X, Chen G, Wang Y, Zhi Q, Liu Y, et al. Dragon (RGMb) induces oxaliplatin resistance in colon cancer cells. Oncotarget. 2016;7:48027-48037 pubmed 出版商 |
| Xiang N, Liu J, Liao Y, Huang Y, Wu Z, Bai Z, et al. Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway. Sci Rep. 2016;6:27583 pubmed 出版商 |
| Nawaz Z, Patil V, Arora A, Hegde A, Arivazhagan A, Santosh V, et al. Cbx7 is epigenetically silenced in glioblastoma and inhibits cell migration by targeting YAP/TAZ-dependent transcription. Sci Rep. 2016;6:27753 pubmed 出版商 |
| Zhou J, Xu Z, Li N, Zhao Y, Wang Z, Xiao W. Identification of cardioprotective agents from traditional Chinese medicine against oxidative damage. Mol Med Rep. 2016;14:77-88 pubmed 出版商 |
| Phelps Polirer K, Abt M, Smith D, Yeh E. Co-Targeting of JNK and HUNK in Resistant HER2-Positive Breast Cancer. PLoS ONE. 2016;11:e0153025 pubmed 出版商 |
| Lin Y, Zhuang J, Li H, Zhu G, Zhou S, Li W, et al. Vaspin attenuates the progression of atherosclerosis by inhibiting ER stress-induced macrophage apoptosis in apoE‑/‑ mice. Mol Med Rep. 2016;13:1509-16 pubmed 出版商 |
| Kim J, Son Y, Bae M, Lee S, Park S, Lee H, et al. Continuous Exposure to Low-Dose-Rate Gamma Irradiation Reduces Airway Inflammation in Ovalbumin-Induced Asthma. PLoS ONE. 2015;10:e0143403 pubmed 出版商 |
| Qi L, Sun X, Li F, Zhu B, Braun F, Liu Z, et al. HMGB1 Promotes Mitochondrial Dysfunction-Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation. PLoS ONE. 2015;10:e0142901 pubmed 出版商 |
| Bai A, Moss A, Rothweiler S, Serena Longhi M, Wu Y, Junger W, et al. NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine. Nat Commun. 2015;6:8819 pubmed 出版商 |
| Hou J, Ma J, Yu K, Li W, Cheng C, Bao L, et al. Non-thermal plasma treatment altered gene expression profiling in non-small-cell lung cancer A549 cells. BMC Genomics. 2015;16:435 pubmed 出版商 |
| Garcia D, de Castro Faria Neto H, da Silva C, de Souza e Souza K, Gonçalves de Albuquerque C, Silva A, et al. Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. Mol Cancer. 2015;14:105 pubmed 出版商 |
| Li J, Xiang S, Zhang Q, Wu J, Tang Q, Zhou J, et al. Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C. J Exp Clin Cancer Res. 2015;34:46 pubmed 出版商 |
| Wang Z, Xiong F, Xie X, Chen D, Pan J, Cheng L. Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress. BMC Nephrol. 2015;16:44 pubmed 出版商 |
| Boeddeker S, Baston Buest D, Fehm T, Kruessel J, Hess A. Decidualization and syndecan-1 knock down sensitize endometrial stromal cells to apoptosis induced by embryonic stimuli. PLoS ONE. 2015;10:e0121103 pubmed 出版商 |
| Zeng Z, Leng T, Feng X, Sun H, Inoue K, Zhu L, et al. Silencing TRPM7 in mouse cortical astrocytes impairs cell proliferation and migration via ERK and JNK signaling pathways. PLoS ONE. 2015;10:e0119912 pubmed 出版商 |
| Li C, Lun W, Zhao X, Lei S, Guo Y, Ma J, et al. Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells. Mediators Inflamm. 2015;2015:434692 pubmed 出版商 |
| Bozic I, Savic D, Laketa D, Bjelobaba I, Milenkovic I, Pekovic S, et al. Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia. PLoS ONE. 2015;10:e0118372 pubmed 出版商 |
| Shaw A, Pickup M, Chytil A, Aakre M, Owens P, Moses H, et al. TGFβ signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. PLoS ONE. 2015;10:e0117908 pubmed 出版商 |
| Mikami Y, Matsuzaki H, Horie M, Noguchi S, Jo T, Narumoto O, et al. Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells. PLoS ONE. 2014;9:e114791 pubmed 出版商 |
| Lancaster G, Kraakman M, Kammoun H, Langley K, Estevez E, Banerjee A, et al. The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice. PLoS ONE. 2014;9:e111524 pubmed 出版商 |
| Yong S, Lim M, Low C, Wong B. Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice. Sci Rep. 2014;4:6580 pubmed 出版商 |
| Denoyelle C, Lambert B, Meryet Figuière M, Vigneron N, Brotin E, Lecerf C, et al. miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation. Cell Death Dis. 2014;5:e1445 pubmed 出版商 |
| Liu J, Lin X, Yang X, Zhou L, He S, Zhuang S, et al. A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of hepatoma cells. Nucleic Acids Res. 2014;42:12041-51 pubmed 出版商 |
| Li T, Song T, Ni L, Yang G, Song X, Wu L, et al. The p-ERK-p-c-Jun-cyclinD1 pathway is involved in proliferation of smooth muscle cells after exposure to cigarette smoke extract. Biochem Biophys Res Commun. 2014;453:316-20 pubmed 出版商 |
| Kong Q, Hua H, Cui A, Shao T, Song P, Jiang Y. SP600125 induces Src and type I IGF receptor phosphorylation independent of JNK. Int J Mol Sci. 2014;15:16246-56 pubmed 出版商 |
| Trucco L, Andreoli V, Núñez N, Maccioni M, Bocco J. Krüppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene. FASEB J. 2014;28:5262-76 pubmed 出版商 |
| Yu G, Lee Y, Cheng C, Wu C, Song J, Gallick G, et al. RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival. Mol Cancer Res. 2015;13:348-57 pubmed 出版商 |
| Chang Y, Chang W, Hung K, Yang D, Cheng Y, Liao Y, et al. The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress. Front Aging Neurosci. 2014;6:191 pubmed 出版商 |
| Wang L, Chiou S, Shen Y, Yen F, Ding H, Wu M. Anti-inflammatory effect and mechanism of the green fruit extract of Solanum integrifolium Poir. Biomed Res Int. 2014;2014:953873 pubmed 出版商 |
| Luo X, Tai W, Sun L, Qiu Q, Xia Z, Chung S, et al. Central administration of C-X-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice. PLoS ONE. 2014;9:e104860 pubmed 出版商 |
| Mori K, Kitazawa R, Kondo T, Mori M, Hamada Y, Nishida M, et al. Diabetic osteopenia by decreased ?-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene. PLoS ONE. 2014;9:e102797 pubmed 出版商 |
| Pavese J, Ogden I, Voll E, Huang X, Xu L, Jovanovic B, et al. Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis. PLoS ONE. 2014;9:e102289 pubmed 出版商 |
| Lee H, Lee H, Chin H, Kim K, Lee D. ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells. Oncotarget. 2014;5:5138-52 pubmed |
| Li Z, Park H, Shi Z, Li Z, Pham C, Du Y, et al. Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs. Oncotarget. 2014;5:3197-209 pubmed |
| Zhang J, Clark K, Lawrence T, Peggie M, Cohen P. An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation. Biochem J. 2014;461:531-7 pubmed 出版商 |
| Chen W, Zhang L, Zhang K, Zhou B, Kuo M, Hu S, et al. Reciprocal regulation of autophagy and dNTP pools in human cancer cells. Autophagy. 2014;10:1272-84 pubmed 出版商 |
| Zhou H, Guo W, Zhao Y, Wang Y, Zha R, Ding J, et al. MicroRNA-135a acts as a putative tumor suppressor by directly targeting very low density lipoprotein receptor in human gallbladder cancer. Cancer Sci. 2014;105:956-65 pubmed 出版商 |
| Guo Y, Riley K, Iwasaki A, Steitz J. Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function. Mol Cell. 2014;54:67-79 pubmed 出版商 |
| Ting C, Huang H, Huang T, Wu C, Chen J. The mechanisms by which pardaxin, a natural cationic antimicrobial peptide, targets the endoplasmic reticulum and induces c-FOS. Biomaterials. 2014;35:3627-40 pubmed 出版商 |
| Ruiz E, Oeztuerk Winder F, Ventura J. A paracrine network regulates the cross-talk between human lung stem cells and the stroma. Nat Commun. 2014;5:3175 pubmed 出版商 |
| Kosla J, Dvorakova M, Dvorak M, Cermák V. Effective myofibroblast dedifferentiation by concomitant inhibition of TGF-? signaling and perturbation of MAPK signaling. Eur J Cell Biol. 2013;92:363-73 pubmed 出版商 |
| Zeng L, Yao Y, Wang D, Chen X. Effect of microcavitary alginate hydrogel with different pore sizes on chondrocyte culture for cartilage tissue engineering. Mater Sci Eng C Mater Biol Appl. 2014;34:168-75 pubmed 出版商 |
| Sun P, Zhou K, Wang S, Li P, Chen S, Lin G, et al. Involvement of MAPK/NF-κB signaling in the activation of the cholinergic anti-inflammatory pathway in experimental colitis by chronic vagus nerve stimulation. PLoS ONE. 2013;8:e69424 pubmed 出版商 |
| Cao Y, Xia D, Qi S, Du J, Ma P, Wang S, et al. Epiregulin can promote proliferation of stem cells from the dental apical papilla via MEK/Erk and JNK signalling pathways. Cell Prolif. 2013;46:447-56 pubmed 出版商 |
| Kook S, Cho J, Morrison A, Wiener E, Lee S, Scadden D, et al. The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity. Cell Death Dis. 2013;4:e703 pubmed 出版商 |
| Tezuka Y, Okada M, Tada Y, Yamauchi J, Nishigori H, Sanbe A. Regulation of neurite growth by inorganic pyrophosphatase 1 via JNK dephosphorylation. PLoS ONE. 2013;8:e61649 pubmed 出版商 |
| Abadi A, Crane J, Ogborn D, Hettinga B, Akhtar M, Stokl A, et al. Supplementation with ?-lipoic acid, CoQ10, and vitamin E augments running performance and mitochondrial function in female mice. PLoS ONE. 2013;8:e60722 pubmed 出版商 |
| Orejana L, Barros Miñones L, Aguirre N, Puerta E. Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model. Exp Gerontol. 2013;48:565-71 pubmed 出版商 |
| Garcia Garcia F, Mullol J, Perez Gonzalez M, Pujols L, Alobid I, Roca Ferrer J, et al. Signal transduction pathways (MAPKs, NF-?B, and C/EBP) regulating COX-2 expression in nasal fibroblasts from asthma patients with aspirin intolerance. PLoS ONE. 2012;7:e51281 pubmed 出版商 |
| Barros Miñones L, Orejana L, Goni Allo B, Suquía V, Hervias I, Aguirre N, et al. Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate. Br J Pharmacol. 2013;168:1820-34 pubmed 出版商 |
| Mufson E, He B, Nadeem M, Perez S, Counts S, Leurgans S, et al. Hippocampal proNGF signaling pathways and ?-amyloid levels in mild cognitive impairment and Alzheimer disease. J Neuropathol Exp Neurol. 2012;71:1018-29 pubmed 出版商 |
| Moriyama M, Moriyama H, Ueda A, Nishibata Y, Okura H, Ichinose A, et al. Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling. BMC Cell Biol. 2012;13:21 pubmed 出版商 |
| Skrypek N, Duchene B, Hebbar M, Leteurtre E, Van Seuningen I, Jonckheere N. The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family. Oncogene. 2013;32:1714-23 pubmed 出版商 |
| Schindler M, Fabre C, de Weille J, Carreau S, Mersel M, Bakalara N. Disruption of nongenomic testosterone signaling in a model of spinal and bulbar muscular atrophy. Mol Endocrinol. 2012;26:1102-16 pubmed 出版商 |
| Wang L, Kou M, Weng C, Hu L, Wang Y, Wu M. Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-?B, and MAPK pathways. Arch Toxicol. 2012;86:879-96 pubmed 出版商 |
| Li J, Deng J, Sheng W, Zuo Z. Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice. Pharmacol Biochem Behav. 2012;101:564-74 pubmed 出版商 |
| Sun L, Zhao R, Zhang L, Zhang T, Xin W, Lan X, et al. Salvianolic acid A inhibits PDGF-BB induced vascular smooth muscle cell migration and proliferation while does not constrain endothelial cell proliferation and nitric oxide biosynthesis. Molecules. 2012;17:3333-47 pubmed 出版商 |
| Alrashdan Y, Alkhouri H, Chen E, Lalor D, Poniris M, Henness S, et al. Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement. Am J Physiol Lung Cell Mol Physiol. 2012;302:L1118-27 pubmed 出版商 |
| Su J, Yen J, Li S, Weng C, Lin M, Ho C, et al. 3',4'-didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells. Free Radic Biol Med. 2012;52:126-41 pubmed 出版商 |
| Zhou H, Shen D, Bian Z, Zong J, Deng W, Zhang Y, et al. Activating transcription factor 3 deficiency promotes cardiac hypertrophy, dysfunction, and fibrosis induced by pressure overload. PLoS ONE. 2011;6:e26744 pubmed 出版商 |
| Francis S, Kramarenko I, Brandon C, Lee F, Baker T, Cunningham L. Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32. Cell Death Dis. 2011;2:e195 pubmed 出版商 |
| Biermann J, Lagrèze W, Schallner N, Schwer C, Goebel U. Inhalative preconditioning with hydrogen sulfide attenuated apoptosis after retinal ischemia/reperfusion injury. Mol Vis. 2011;17:1275-86 pubmed |
| Kim K, Singh R, Strongin R, Moore R, Brard L, Lange T. Organometallic iron(III)-salophene exerts cytotoxic properties in neuroblastoma cells via MAPK activation and ROS generation. PLoS ONE. 2011;6:e19049 pubmed 出版商 |
| Tu Y, Tsai Y, Wang L, Wu H, Huang C, Ho C. Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation. J Neuroinflammation. 2011;8:40 pubmed 出版商 |
| Xu B, Gerin I, Miao H, Vu Phan D, Johnson C, Xu R, et al. Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity. PLoS ONE. 2010;5:e14199 pubmed 出版商 |
| Hewer R, Sala Newby G, Wu Y, Newby A, Bond M. PKA and Epac synergistically inhibit smooth muscle cell proliferation. J Mol Cell Cardiol. 2011;50:87-98 pubmed 出版商 |
| Isserlin R, Merico D, Alikhani Koupaei R, Gramolini A, Bader G, Emili A. Pathway analysis of dilated cardiomyopathy using global proteomic profiling and enrichment maps. Proteomics. 2010;10:1316-27 pubmed 出版商 |
| Snow G, Kasper A, Busch A, Schwarz E, Ewings K, Bee T, et al. Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting. BMC Cancer. 2009;9:383 pubmed 出版商 |
| Bromberg White J, Boguslawski E, Duesbery N. Perturbation of mouse retinal vascular morphogenesis by anthrax lethal toxin. PLoS ONE. 2009;4:e6956 pubmed 出版商 |
| Rardin M, Wiley S, Murphy A, Pagliarini D, Dixon J. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem. 2008;283:15440-50 pubmed 出版商 |
