产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
Anti-Catenin Gamma (Plakoglobin) Jup Antibody (Monoclonal, 15F11)
目录 :
MA1012
规格 :
100μg/vial
价格 :
315美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
15F11
反应物种 :
人类, 大鼠, 牛
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
图像
图像 1 :
Anti-Catenin gamma(Plakoglobin) antibody (monoclonal), MA1012, Western blotting. Lane 1: MCF-7 Cell Lysate. Lane 2: HELA Cell Lysate. Lane 3: MM231 Cell Lysate. Lane 4: HT1080 Cell Lysate.
产品信息
SKU号 :
MA1012
产品名称 :
Anti-Catenin Gamma (Plakoglobin) Jup Antibody (Monoclonal, 15F11)
价格 :
315美元
规格 :
100μg/vial
克隆性 :
单克隆
克隆编号 :
15F11
宿主 :
小鼠
反应物种 :
牛, 人类
前体活性 :
Monkey
应用(s) :
免疫组化, 免疫细胞化学, 免疫印迹
应用细节 :
Immunocytochemistry , 1µg/ml, Human, bovineImmunohistochemistry (Frozen Section), 4µg/ml, Human, bovine Western blot, 2µg/ml, Human, bovine.
应用注释 :
Other applications have not been tested.
Optimal dilutions should be determined by end users.
描述 :
Boster Bio Anti-Catenin Gamma (Plakoglobin) Jup Antibody (Monoclonal, 15F11) catalog # MA1012. Tested in IHC, ICC, WB applications. This antibody reacts with Bovine, Human.
浓度 :
Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.
基因名称 :
JUP
UniProt数据库编号 :
Q6P0K8
免疫原 :
Recombinant chicken plakoglobin.
形式 :
冻干
Contents :
Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
纯化 :
腹水
交叉活性 :
No cross reactivity with other proteins
抗体亚型 :
小鼠IgG1
储存 :
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
重组 :
Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
基因全称 :
Junction plakoglobin
同义词 :
Junction plakoglobin; Jup;
蛋白名 :
Junction plakoglobin
分子量 :
81801分子量
Protein Function :
Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Subcellular Localization :
Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane ; Peripheral membrane protein. Cytoplasmic in a soluble and membrane-associated form.
Recommended Detection Systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(F) and ICC.
Sequence Similarities :
Belongs to the beta-catenin family.
背景 :
Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.
研究种类 :
Actin Etc, Cytoskeleton, Cytoskeleton / Ecm, Microfilaments, Signal Transduction
更多信息或购买 :
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn925.485.4527
公司总部: 美国
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