抗体

Anti-Torsin A TOR1A Rabbit Monoclonal Antibody

M01381

100微升

315美元

单克隆

domestic rabbit

未共轭

BAH-20

免疫印迹, 流式细胞仪

Anti-Torsin A TOR1A Rabbit Monoclonal Antibody

315美元

100微升

单克隆

BAH-20

兔

人类

流式细胞仪, 免疫印迹

免疫印迹1:500-1:2000。 流式细胞仪1:50

Boster Bio Anti-Torsin A TOR1A Rabbit Monoclonal Antibody catalog # M01381. Tested in Flow Cytometry, WB applications. This antibody reacts with Human.

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

TOR1A

O14656

A synthesized peptide derived from human Torsin A

液体

兔IgG在磷酸盐缓冲液, pH值7.4, 150mM氯化钠, 0.02% 叠氮化钠和50% 甘油, 0.4 0.5毫克/毫升BSA

亲和色谱

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Torsin-1A

Torsin-1A; Dystonia 1 protein; Torsin ATPase-1A; 3.6.4.-; Torsin family 1 member A; TOR1A; DQ2, DYT1, TA, TORA;

37809分子量

Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non- neural tissues.

Endoplasmic reticulum lumen. Nucleus membrane; Peripheral membrane protein. Cell projection, growth cone. Cytoplasmic vesicle membrane. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasm, cytoskeleton. Upon oxidative stress, redistributes to protusions from the cell surface (By similarity). Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2.

Widely expressed. Highest levels in kidney and liver. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also highly expressed in the spinal cord.

Cytoskeleton, Cytoskeleton / Ecm, Intermediate Filaments, Nucleus, Signal Transduction, Subcellular Markers, Tags & Cell Markers