抗体

抗人类Ki67抗体

M00254-3

100微升

299美元

多克隆

domestic rabbit

未共轭

多克隆

免疫印迹, 免疫组化, 免疫细胞化学

抗人类Ki67抗体

299美元

100微升

多克隆

兔

人类, 大鼠, 小鼠

免疫组化, 免疫印迹, IF, 免疫细胞化学

WB: 1:1, 000-5, 000。 IF 1:2, 000-5, 000, 免疫组化1:1, 000

Boster Bio Anti-Human Ki67 Antibody catalog # M00254-3. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

MKI67

P46013

Recombinant human construct containing amino acids 1,111-1,490 expressed in and purified from E. coli.

Serum with 5mM NaN 3

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Proliferation marker protein Ki-67

Proliferation marker protein Ki-67 ; Antigen identified by monoclonal antibody Ki-67 ; Antigen KI-67 ; Antigen Ki67 ; MKI67 ;

358694分子量

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Chromosome. Nucleus. Nucleus, nucleolus. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106).

Cancer, Cell Biology, Cell Cycle, Cell Division, Cell Type Marker, Cell Type Markers, Neurogenesis, Neurology Process, Neuron Marker, Neuroscience, Tags & Cell Markers, Tumor Biomarkers