ELISA/assay

Human Tenascin-R ELISA Kit PicoKine®

EK1931

96 wells/kit, with removable strips.

369美元

Human Tenascin-R ELISA Kit PicoKine®

96 wells/kit, with removable strips.

369美元

Human Tenascin-R ELISA Kit PicoKine® (96 Tests). Quantitate Human TNR in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 50pg/ml.

人类

酶联免疫吸附测定

TNR

Q92752

Expression system for standard: NS0; Immunogen sequence: Q32-F1358

There is no detectable cross-reactivity with other relevant proteins.

156 pg/ml - 10,000 pg/ml

<50 pg/ml

cell culture supernatants, serum and plasma (heparin, EDTA)

a单克隆抗体来自小鼠, a生物素多克隆抗体来自山羊

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

腱糖蛋白R

Tenascin-R; TN-R; Janusin; Restrictin; TNR

腱糖蛋白R

Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance.

细胞外间质

Brain specific.

Tenascin-R is a protein that in humans is encoded by the TNR gene. This gene is mapped to 1q25.1. Tenascin-R (TNR) is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion), TNX (TNXB), and TNR. The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues. This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets.

Axonal Guidance Proteins, Cell Adhesion Proteins, Cytoskeleton / Ecm, Developmental Biology, Ecm Proteins, Extracellular Matrix, Growth And Development, Nervous System Development, Neurology Process, Neuroscience, Organogenesis, Signal Transduction