产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗CD63抗原CD63抗体
目录 :
A01080
规格 :
100微升
价格 :
637美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
产品信息
SKU号 :
A01080
产品名称 :
抗CD63抗原CD63抗体
价格 :
637美元
规格 :
100微升
克隆性 :
多克隆
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用(s) :
免疫印迹, 免疫组化, IF
应用细节 :
免疫印迹1:500-1:2000免疫组化1:50-1:200 IF 1:50-1:200
描述 :
Boster Bio Anti-CD63 antigen CD63 Antibody catalog # A01080. Tested in IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
基因名称 :
CD63
UniProt数据库编号 :
P08962
形式 :
液体
Contents :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
纯化 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
储存 :
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
基因全称 :
胰岛素受体
同义词 :
胰岛素受体;IR;2.7。 10.1;CD220;胰岛素受体亚单位甲;胰岛素受体亚单位乙;INSR;
蛋白名 :
胰岛素受体
分子量 :
156333分子量
Protein Function :
Receptor tyrosine kinase which mediates the pleiotropic
actions of insulin. Binding of insulin leads to phosphorylation of
several intracellular substrates, including, insulin receptor
substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling
intermediates. Each of these phosphorylated proteins serve as
docking proteins for other signaling proteins that contain Src-
homology-2 domains (SH2 domain) that specifically recognize
different phosphotyrosine residues, including the p85 regulatory
subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to
the activation of two main signaling pathways: the PI3K-AKT/PKB
pathway, which is responsible for most of the metabolic actions of
insulin, and the Ras-MAPK pathway, which regulates expression of
some genes and cooperates with the PI3K pathway to control cell
growth and differentiation. Binding of the SH2 domains of PI3K to
phosphotyrosines on IRS1 leads to the activation of PI3K and the
generation of phosphatidylinositol- (3, 4, 5)-triphosphate (PIP3),
a lipid second messenger, which activates several PIP3-dependent
serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB.
The net effect of this pathway is to produce a translocation of
the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to
the cell membrane to facilitate glucose transport. Moreover, upon
insulin stimulation, activated AKT/PKB is responsible for: anti-
apoptotic effect of insulin by inducing phosphorylation of BAD;
regulates the expression of gluconeogenic and lipogenic enzymes by
controlling the activity of the winged helix or forkhead (FOX)
class of transcription factors. Another pathway regulated by PI3K-
AKT/PKB activation is mTORC1 signaling pathway which regulates
cell growth and metabolism and integrates signals from insulin.
AKT mediates insulin-stimulated protein synthesis by
phosphorylating TSC2 thereby activating mTORC1 pathway. The
Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell
growth, survival and cellular differentiation of insulin.
Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the
activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to
binding insulin, the insulin receptor can bind insulin-like growth
factors (IGFI and IGFII). Isoform Short has a higher affinity for
IGFII binding. When present in a hybrid receptor with IGF1R, binds
IGF1. PubMed:12138094 shows that hybrid receptors composed of
IGF1R and INSR isoform Long are activated with a high affinity by
IGF1, with low affinity by IGF2 and not significantly activated by
insulin, and that hybrid receptors composed of IGF1R and INSR
isoform Short are activated by IGF1, IGF2 and insulin. In
contrast, PubMed:16831875 shows that hybrid receptors composed of
IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R
and INSR isoform Short have similar binding characteristics, both
bind IGF1 and have a low affinity for insulin.
Subcellular Localization :
Cell membrane; Single-pass type I membrane
protein.
组织特异性 :
Isoform Long and isoform Short are
predominantly expressed in tissue targets of insulin metabolic
effects: liver, adipose tissue and skeletal muscle but are also
expressed in the peripheral nerve, kidney, pulmonary alveoli,
pancreatic acini, placenta vascular endothelium, fibroblasts,
monocytes, granulocytes, erythrocytes and skin. Isoform Short is
preferentially expressed in fetal cells such as fetal fibroblasts,
muscle, liver and kidney. Found as a hybrid receptor with IGF1R in
muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma,
fibroblasts, spleen and placenta (at protein level). Overexpressed
in several tumors, including breast, colon, lung, ovary, and
thyroid carcinomas.
更多信息或购买 :
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn925.485.4527
公司总部: 美国
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