产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗磷酸化AR(Y363)抗体
目录 :
A00542Y363
规格 :
100微升
价格 :
380美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
产品信息
SKU号 :
A00542Y363
产品名称 :
抗磷酸化AR(Y363)抗体
价格 :
380美元
规格 :
100微升
克隆性 :
多克隆
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用(s) :
免疫印迹, 酶联免疫吸附测定
应用细节 :
免疫印迹1:500-1:2000酶联免疫吸附测定1:10000
描述 :
Boster Bio Anti-Phospho-AR (Y363) Antibody catalog # A00542Y363. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
浓度 :
1毫克/毫升
基因名称 :
AR
UniProt数据库编号 :
P10275
免疫原 :
Synthesized peptide derived from human AR around the phosphorylation site of Y363.
形式 :
液体
Contents :
液体PBS含50% 甘油, 0.5% BSA和0.02% 叠氮化钠
纯化 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
抗体亚型 :
IgG
储存 :
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
基因全称 :
Baculoviral IAP repeat-containing protein 5
同义词 :
Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; BIRC5; API4, IAP4;
蛋白名 :
Baculoviral IAP repeat-containing protein 5
分子量 :
16389分子量
Protein Function :
Multitasking protein that has dual roles in promoting
cell proliferation and preventing apoptosis (PubMed:9859993,
PubMed:21364656, PubMed:20627126). Component of a chromosome
passage protein complex (CPC) which is essential for chromosome
alignment and segregation during mitosis and cytokinesis
(PubMed:16322459). Acts as an important regulator of the
localization of this complex; directs CPC movement to different
locations from the inner centromere during prometaphase to midbody
during cytokinesis and participates in the organization of the
center spindle by associating with polymerized microtubules
(PubMed:20826784). Involved in the recruitment of CPC to
centromeres during early mitosis via association with histone H3
phosphorylated at 'Thr-3' (H3pT3) during mitosis
(PubMed:20929775). The complex with RAN plays a role in mitotic
spindle formation by serving as a physical scaffold to help
deliver the RAN effector molecule TPX2 to microtubules
(PubMed:18591255). May counteract a default induction of apoptosis
in G2/M phase (PubMed:9859993). The acetylated form represses
STAT3 transactivation of target gene promoters (PubMed:20826784).
May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3
and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear
to play vital roles in mitosis (PubMed:12773388, PubMed:16291752).
Isoform 3 shows a marked reduction in its anti-apoptotic effects
when compared with the displayed wild-type isoform
(PubMed:10626797).
Subcellular Localization :
细胞质
组织特异性 :
Expressed only in fetal kidney and liver, and
to lesser extent, lung and brain (PubMed:10626797). Abundantly
expressed in adenocarcinoma (lung, pancreas, colon, breast, and
prostate) and in high-grade lymphomas (PubMed:14741722,
PubMed:16329164). Also expressed in various renal cell carcinoma
cell lines (PubMed:10626797). Expressed in cochlea including the
organ of Corti, the lateral wall, the interdental cells of the
Limbus as well as in Schwann cells and cells of the cochlear nerve
and the spiral ganglions (at protein level). Not expressed in
cells of the inner and outer sulcus or the Reissner's membrane (at
protein level) (PubMed:21364656, PubMed:20627126).
更多信息或购买 :
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn925.485.4527
公司总部: 美国
Premium Provider of Antibodies and ELISA Kits
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