产品简要
公司名称 :
武汉博士德生物工程有限公司
产品类型 :
抗体
产品名称 :
抗磷酸化表皮生长因子受体(S1071)抗体
目录 :
A00023S1071
规格 :
100微升
价格 :
380美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
产品信息
SKU号 :
A00023S1071
产品名称 :
抗磷酸化表皮生长因子受体(S1071)抗体
价格 :
380美元
规格 :
100微升
克隆性 :
多克隆
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用(s) :
免疫印迹, 酶联免疫吸附测定
应用细节 :
免疫印迹1:500-1:2000酶联免疫吸附测定1:5000
描述 :
Boster Bio Anti-Phospho-EGFR (S1071) Antibody catalog # A00023S1071. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
浓度 :
1毫克/毫升
基因名称 :
表皮生长因子受体
UniProt数据库编号 :
P00533
免疫原 :
Synthesized peptide derived from human EGFR around the phosphorylation site of S1071.
形式 :
液体
Contents :
液体PBS含50% 甘油, 0.5% BSA和0.02% 叠氮化钠
纯化 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
抗体亚型 :
IgG
储存 :
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
基因全称 :
蛋白S100-A9
同义词 :
Protein S100-A9; Calgranulin-B; Calprotectin L1H subunit; Leukocyte L1 complex heavy chain; Migration inhibitory factor-related protein 14; MRP-14; p14; S100 calcium-binding protein A9; S100A9; CAGB, CFAG, MRP14;
蛋白名 :
蛋白S100-A9
分子量 :
13242分子量
Protein Function :
S100A9 is a calcium- and zinc-binding protein which
plays a prominent role in the regulation of inflammatory processes
and immune response. It can induce neutrophil chemotaxis,
adhesion, can increase the bactericidal activity of neutrophils by
promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2
and can induce degranulation of neutrophils by a MAPK-dependent
mechanism. Predominantly found as calprotectin (S100A8/A9) which
has a wide plethora of intra- and extracellular functions. The
intracellular functions include: facilitating leukocyte
arachidonic acid trafficking and metabolism, modulation of the
tubulin-dependent cytoskeleton during migration of phagocytes and
activation of the neutrophilic NADPH-oxidase. Activates NADPH-
oxidase by facilitating the enzyme complex assembly at the cell
membrane, transferring arachidonic acid, an essential cofactor, to
the enzyme complex and S100A8 contributes to the enzyme assembly
by directly binding to NCF2/P67PHOX. The extracellular functions
involve proinflammatory, antimicrobial, oxidant-scavenging and
apoptosis-inducing activities. Its proinflammatory activity
includes recruitment of leukocytes, promotion of cytokine and
chemokine production, and regulation of leukocyte adhesion and
migration. Acts as an alarmin or a danger associated molecular
pattern (DAMP) molecule and stimulates innate immune cells via
binding to pattern recognition receptors such as Toll-like
receptor 4 (TLR4) and receptor for advanced glycation endproducts
(AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-
kappa-B signaling pathways resulting in the amplification of the
proinflammatory cascade. Has antimicrobial activity towards
bacteria and fungi and exerts its antimicrobial activity probably
via chelation of Zn (2+) which is essential for microbial growth.
Can induce cell death via autophagy and apoptosis and this occurs
through the cross-talk of mitochondria and lysosomes via reactive
oxygen species (ROS) and the process involves BNIP3. Can regulate
neutrophil number and apoptosis by an anti-apoptotic effect;
regulates cell survival via ITGAM/ITGB and TLR4 and a signaling
mechanism involving MEK-ERK. Its role as an oxidant scavenger has
a protective role in preventing exaggerated tissue damage by
scavenging oxidants. Can act as a potent amplifier of inflammation
in autoimmunity as well as in cancer development and tumor spread.
Has transnitrosylase activity; in oxidatively-modified low-
densitity lipoprotein (LDL (ox))-induced S-nitrosylation of GAPDH
on 'Cys-247' proposed to transfer the NO moiety from NOS2/iNOS to
GAPDH via its own S-nitrosylated Cys-3. The iNOS-S100A8/A9
transnitrosylase complex is proposed to also direct selective
inflammatory stimulus-dependent S-nitrosylation of multiple
targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-
x-x-[DE] motif.
Subcellular Localization :
Secreted. Cytoplasm. Cytoplasm,
cytoskeleton. Cell membrane; Peripheral membrane protein.
Predominantly localized in the cytoplasm. Upon elevation of
the intracellular calcium level, translocated from the cytoplasm
to the cytoskeleton and the cell membrane. Upon neutrophil
activation or endothelial adhesion of monocytes, is secreted via a
microtubule-mediated, alternative pathway.
组织特异性 :
Calprotectin (S100A8/9) is predominantly
expressed in myeloid cells. Except for inflammatory conditions,
the expression is restricted to a specific stage of myeloid
differentiation since both proteins are expressed in circulating
neutrophils and monocytes but are absent in normal tissue
macrophages and lymphocytes. Under chronic inflammatory
conditions, such as psoriasis and malignant disorders, also
expressed in the epidermis. Found in high concentrations at local
sites of inflammation or in the serum of patients with
inflammatory diseases such as rheumatoid, cystic fibrosis,
inflammatory bowel disease, Crohn's disease, giant cell arteritis,
cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus,
and progressive systemic sclerosis. Involved in the formation and
deposition of amyloids in the aging prostate known as corpora
amylacea inclusions. Strongly up-regulated in many tumors,
including gastric, esophageal, colon, pancreatic, bladder,
ovarian, thyroid, breast and skin cancers.
更多信息或购买 :
公司信息
武汉博士德生物工程有限公司
3942 B Valley Ave
Pleasanton, CA 94566
Pleasanton, CA 94566
boster@bosterbio.com
http://www.boster.com.cn925.485.4527
公司总部: 美国
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