产品简要
公司名称 :
BioLegend
其他品牌 :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
产品类型 :
抗体
产品名称 :
Purified (azide-free) anti-APP C-Terminal Fragment
目录 :
802803
规格 :
25微升
价格 :
112美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
C1/6.1
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 22
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:2000; 图 1i
Han X, Wang C, Song L, Wang X, Tang S, Hou T, et al. KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion. EBioMedicine. 2022;78:103980 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6a
  • 免疫沉淀; 人类; 图 8e
Kim W, Watanabe H, Lomoio S, Tesco G. Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo. J Biol Chem. 2021;296:100372 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 图 1b
Arber C, Lovejoy C, Harris L, Willumsen N, Alatza A, Casey J, et al. Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis. Cell Rep. 2021;34:108615 pubmed 出版商
Hung C, Tuck E, Stubbs V, van der Lee S, Aalfs C, van Spaendonk R, et al. SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network. Cell Rep. 2021;35:109259 pubmed 出版商
Bourdenx M, Martín Segura A, Scrivo A, Rodriguez Navarro J, Kaushik S, Tasset I, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021;184:2696-2714.e25 pubmed 出版商
Lingel A, Lin H, Gavriel Y, Weaver E, Polepole P, Lopez V, et al. Amyloid precursor protein is a restriction factor that protects against Zika virus infection in mammalian brains. J Biol Chem. 2020;295:17114-17127 pubmed 出版商
Lundgren J, Vandermeulen L, Sandebring Matton A, Ahmed S, Winblad B, Di Luca M, et al. Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain. BMC Neurosci. 2020;21:6 pubmed 出版商
Arber C, Villegas Llerena C, Toombs J, Pocock J, Ryan N, Fox N, et al. Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout. Brain Commun. 2019;1:fcz024 pubmed 出版商
Arber C, Toombs J, Lovejoy C, Ryan N, Paterson R, Willumsen N, et al. Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta. Mol Psychiatry. 2019;: pubmed 出版商
Reichenbach N, Delekate A, Plescher M, Schmitt F, Krauss S, Blank N, et al. Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model. EMBO Mol Med. 2019;11: pubmed 出版商
Hung C, Livesey F. Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease. Cell Rep. 2018;25:3647-3660.e2 pubmed 出版商
Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, et al. P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model. J Exp Med. 2018;215:1649-1663 pubmed 出版商
de Coninck D, Schmidt T, Schloetel J, Lang T. Packing Density of the Amyloid Precursor Protein in the Cell Membrane. Biophys J. 2018;114:1128-1141 pubmed 出版商
Miranda A, Lasiecka Z, Xu Y, Neufeld J, Shahriar S, Simoes S, et al. Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures. Nat Commun. 2018;9:291 pubmed 出版商
Jean Louis T, Rockwell P, Figueiredo Pereira M. Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α- and β-secretases: relevance to Alzheimer's disease. Neurobiol Aging. 2018;62:130-145 pubmed 出版商
Williamson R, Laulagnier K, Miranda A, Fernandez M, Wolfe M, Sadoul R, et al. Disruption of amyloid precursor protein ubiquitination selectively increases amyloid ? (A?) 40 levels via presenilin 2-mediated cleavage. J Biol Chem. 2017;292:19873-19889 pubmed 出版商
Sogorb Esteve A, García Ayllón M, Llansola M, Felipo V, Blennow K, Saez Valero J. Inhibition of γ-Secretase Leads to an Increase in Presenilin-1. Mol Neurobiol. 2018;55:5047-5058 pubmed 出版商
García Ayllón M, Lopez Font I, Boix C, Fortea J, Sanchez Valle R, Lleo A, et al. C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease. Sci Rep. 2017;7:2477 pubmed 出版商
Kotfis K, Zegan Barańska M, Szydłowski Ł, Zukowski M, Ely E. Methods of pain assessment in adult intensive care unit patients - Polish version of the CPOT (Critical Care Pain Observation Tool) and BPS (Behavioral Pain Scale). Anaesthesiol Intensive Ther. 2017;49:66-72 pubmed 出版商
Paschkowsky S, Hamzé M, Oestereich F, Munter L. Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4. J Biol Chem. 2016;291:21903-21912 pubmed
Corbett G, Gonzalez F, Pahan K. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A. 2015;112:8445-50 pubmed 出版商
Jiang Y, Mullaney K, Peterhoff C, Che S, Schmidt S, Boyer Boiteau A, et al. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci U S A. 2010;107:1630-5 pubmed 出版商
产品信息
抗原 :
APP C-Terminal Fragment
Apps. Abbrev. :
西方墨点法, 免疫细胞化学, 免疫沉淀
目录 :
802803
克隆 :
C1/6.1
产品 :
Purified (azide-free) anti-APP C-Terminal Fragment
抗体亚型 :
小鼠IgG1
其他名称 :
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
规格 :
25微升
价格(美元) :
112美元
反应物种 :
人类, 小鼠, 大鼠
克隆性 :
单克隆
宿主 :
小鼠
共轭标签/标签/标记 :
PUREAF
免疫原 :
This antibody was raised against the conserved carboxyl-terminal 20 residues of APP (residues 676-695 of APP695).
应用注释 :
This antibody is effective in immunoblotting (WB), immunocytochemistry (ICC), and immunoprecipitation (IP).
更多信息或购买 :
公司信息
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
1-858-455-9588
公司总部: 美国
Biolegend公司为生物医学研究提供顶级的抗体及试剂产品,旨在加速生命科学领域的研发工作。