抗体

抗伽玛突触核蛋白抗体

APZ-037

1 X 0.2毫升

637美元

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

APZ-037

Primary Antibody>Intracellular>Non-Labeled

Insert

抗伽玛突触核蛋白抗体

Anti-Gamma-Synuclein Antibody (#APZ-037) is a highly specific antibody directed against an epitope of the rat protein. It can be used in western blot analysis. It has been designed to recognize γ-Synuclein from mouse and rat samples. The antibody will not recognize the protein from human samples.

A兔多克隆抗体伽玛突触核蛋白

BLP-PZ037

γ-Synuclein, Breast Cancer-Specific Gene 1 Protein, BCSG1, Persyn, Synoretin, SNCG

伽玛突触核蛋白

Neural Signaling > Scaffolding proteins > Antibodies

未共轭

IF, 免疫组化, 免疫印迹

兔

多克隆

兔IgG

SNCG

小鼠(试验);大鼠(试验)

Mouse – identical.

Neurite outgrowth inhibitor receptor 1 (NgR1, Nogo Receptor) is a glycosylphosphatidylinositol (GPI) transmembrane protein expressed on the surface of axons in the CNS. Its key binding domain is an extracellular leucine-rich repeat domain that interacts with Myelin-associated inhibitory factors (MAIFs) composed of MAG, Neurite outgrowth inhibitor (Nogo)-A, and OMgp1,2. NgR1 binds to Neurite outgrowth inhibitor (Nogo) through a short hydrophilic loop between two hydrophobic domains. This binding activates intracellular molecular switches through the heteromerization with NgR1 co-receptors, p75NTR and LINGO-1. This process facilitates neurite outgrowth dynamics; it also governs the plasticity of the CNS at the axo-dendritic and axo-glial levels3. During CNS neurodegenerative disorders and in animal models of inflammatory demyelination, MAIFs, containing Nogo, accumulate and therefore there is an increased binding to their cognate receptor. This marks Nogo-NgR1 interaction as a potential target of new therapeutics for neurodegenerative diseases4.

合成肽

intracellular

C末端

(C)RKEDLEPPAQDQE, corresponding to amino acid residues 96 - 108 of rat γ-Synuclein

Peptide (C)RKEDLEPPAQDQE, corresponding to amino acid residues 96 - 108 of rat γ-Synuclein (Accession O76070). Intracellular, C-terminus.

1 X 0.2毫升

0.8毫克/毫升

08毫克/毫升

磷酸盐缓冲液(PBS)

pH值7.4

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

冻干粉末

Affinity purified on immobilized antigen

-20°C

O76070

Reconstitution: 1 X 0.2 ml double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

1

0.2

毫升

637美元