抗体

豚鼠抗PSD-95抗体

APZ-009-GP

1 X 0.2毫升

673美元

多克隆

豚鼠

未共轭

人类, 小鼠, 大鼠

APZ-009-GP

Primary Antibody>Intracellular>Non-Labeled

Insert

豚鼠抗PSD-95抗体

Guinea Pig Anti-PSD-95 Antibody (#APZ-009-GP) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot applications. It has been designed to recognize PSD-95 from rat, mouse, and human samples. n nThe antigen used to immunize guinea pigs is the same as Anti-PSD-95 Antibody (#APZ-009) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation and more.

A豚鼠多克隆抗体PSD-95

BLP-PZ009

Postsynaptic density protein 95, Discs large homolog 4, DLG4, Synapse-associated protein 90, SAP-90, Tax interaction protein 15, MRD62

PSD-95

未共轭

免疫印迹

豚鼠

多克隆

豚鼠总数IgG

DLG4

人类(试验);小鼠(试验);大鼠(试验)

Rat, mouse – identical.

β-Adrenergic receptors (βAR) belong to the superfamily of G-protein coupled receptors (GPCRs). βAR stimulation by the sympathetic nervous system or circulating catecholamines is involved in peripheral blood circulation, metabolic regulation, muscle contraction, and central neural activities. In the heart, acute βAR stimulation serves as the most powerful means to regulate cardiac output in response to a fight-or-flight situation. There are three βAR subtypes, β1AR, β2AR and β3AR, in cardiac myocytes1. The receptors consist of seven membrane-spanning domains, three intra- and three extracellular loops, an extracellular N-terminal domain, and an intracellular C-terminal tail2. β1AR is the predominant receptor subtype expressed in human cardiomyocytes. β1AR is also expressed in the kidney3. It has been implicated in adipogenesis and memory formation4. β1AR has been widely connected with heart disease. Both the downregulation and overstimulation of β1AR have been connected to myocyte apoptosis. In addition, chronic heart failure is characterized by abnormalities in β1AR signal transduction. It was demonstrated that heart failure is also inducible in animal models by overexpression of components of the β1AR signal transduction cascade. Transgenic mice overexpressing β1AR develop, with aging, heart failure similar to that observed in dilated cardiomyopathy in humans5.

合成肽

intracellular

Intracellular

(C)KDWGSSSGSQGRED, corresponding to amino acid residues 505-518 of human PSD-95

Peptide (C)KDWGSSSGSQGRED, corresponding to amino acid residues 505-518 of human PSD-95 (Accession P78352). Intracellular, between the SH3 and the GK-like domains.

1 X 0.2毫升

0.8毫克/毫升

08毫克/毫升

磷酸盐缓冲液(PBS)

pH值7.4

1% BSA, 0.05% NaN3 (% of reconstituted antibody)

Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

冻干粉末

Affinity purified on immobilized antigen

-20°C

P78352

Reconstitution: 1 X 0.2 ml double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C, as long as it is in its original form, it can last a minimum of 3 years this way. The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

1

0.2

毫升

673美元