参考文献 |
---|
Kumar P, Courtes M, Lemmers C, Le Digarcher A, Coku I, Monteil A, et al. Functional mapping of microRNA promoters with dCas9 fused to transcriptional regulators. Front Genet. 2023;14:1147222 pubmed 出版商
|
Ali T, Rogala S, Krause N, Bains J, Melissari M, W xe4 hrisch S, et al. Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA triplex element. Nucleic Acids Res. 2023;51:6227-6237 pubmed 出版商
|
Sgro A, Cursons J, Waryah C, Woodward E, Foroutan M, Lyu R, et al. Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma. Clin Epigenetics. 2023;15:73 pubmed 出版商
|
Jin Q, Liu X, Zhuang Z, Huang J, Gou S, Shi H, et al. Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation. Genome Biol. 2023;24:8 pubmed 出版商
|
Oo J, P xe1 lfi K, Warwick T, Wittig I, Prieto Garcia C, Matkovic V, et al. Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2. Cell Rep. 2022;41:111670 pubmed 出版商
|
Leung H, Foo G, VanDongen A. Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer's Disease. Biomedicines. 2022;10: pubmed 出版商
|
Wang J, Wang A, Tian K, Hua X, Zhang B, Zheng Y, et al. A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors. Cell Discov. 2022;8:74 pubmed 出版商
|
Wang K, Escobar M, Li J, Mahata B, Goell J, Shah S, et al. Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions. Nucleic Acids Res. 2022;50:7842-7855 pubmed 出版商
|
Shen J, Huang Q, Jia W, Feng S, Liu L, Li X, et al. YAP1 induces invadopodia formation by transcriptionally activating TIAM1 through enhancer in breast cancer. Oncogene. 2022;: pubmed 出版商
|
Engelhard C, Huang C, Khani S, Kaspárek P, Prochazka J, Rozman J, et al. Comprehensive Transcriptional Profiling and Mouse Phenotyping Reveals Dispensable Role for Adipose Tissue Selective Long Noncoding RNA Gm15551. Noncoding RNA. 2022;8: pubmed 出版商
|
Nemir M, Kay M, Maison D, Berthonneche C, Sarre A, Plaisance I, et al. Inhibition of the NOTCH1 Pathway in the Stressed Heart Limits Fibrosis and Promotes Recruitment of Non-Myocyte Cells into the Cardiomyocyte Fate. J Cardiovasc Dev Dis. 2022;9: pubmed 出版商
|
Cebola I. Deletion of Regulatory Elements with All-in-One CRISPR-Cas9 Vectors. Methods Mol Biol. 2021;2351:321-334 pubmed 出版商
|
Frank L, Weinmann R, Erdel F, Trojanowski J, Rippe K. Transcriptional Activation of Heterochromatin by Recruitment of dCas9 Activators. Methods Mol Biol. 2021;2351:307-320 pubmed 出版商
|
Zeng J, Xu H, Huang C, Sun Y, Xiao H, Yu G, et al. CD46 splice variant enhances translation of specific mRNAs linked to an aggressive tumor cell phenotype in bladder cancer. Mol Ther Nucleic Acids. 2021;24:140-153 pubmed 出版商
|
Hamann M, Ehmele P, Verdikt R, Bialek Waldmann J, Virdi S, Gunther T, et al. Transcriptional behavior of the HIV-1 promoter in context of the BACH2 prominent proviral integration gene. Virus Res. 2021;293:198260 pubmed 出版商
|
Velazquez J, LeGraw R, Moghadam F, Tan Y, Kilbourne J, Maggiore J, et al. Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids. Cell Syst. 2021;12:41-55.e11 pubmed 出版商
|
Ruan X, Li P, Ma Y, Jiang C, Chen Y, Shi Y, et al. Identification of human long noncoding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasis. J Clin Invest. 2021;131: pubmed 出版商
|
Knapp D, Fulga T. Harnessing tRNA for Processing Ability and Promoter Activity. Methods Mol Biol. 2021;2162:89-114 pubmed 出版商
|
Lin S, Wu H, Yeh L, Yang C, Kao S, Chang K. Activation of the miR-371/372/373 miRNA Cluster Enhances Oncogenicity and Drug Resistance in Oral Carcinoma Cells. Int J Mol Sci. 2020;21: pubmed 出版商
|
Dai Y, Luo W, Yue X, Ma W, Wang J, Chang J. Identification and characterization of a new isoform of small GTPase RhoE. Commun Biol. 2020;3:572 pubmed 出版商
|
Moghadam F, LeGraw R, Velazquez J, Yeo N, Xu C, Park J, et al. Synthetic immunomodulation with a CRISPR super-repressor in vivo. Nat Cell Biol. 2020;22:1143-1154 pubmed 出版商
|
Kirchner S, Reuter S, Westphal A, Mrowka R. Decipher the complexity of cis-regulatory regions by a modified Cas9. PLoS ONE. 2020;15:e0235530 pubmed 出版商
|
Eismann B, Krieger T, Beneke J, Bulkescher R, Adam L, Erfle H, et al. Automated 3D light-sheet screening with high spatiotemporal resolution reveals mitotic phenotypes. J Cell Sci. 2020;133: pubmed 出版商
|
Kulcsár P, Tálas A, Tóth E, Nyeste A, Ligeti Z, Welker Z, et al. Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5'G-extended sgRNAs. Nat Commun. 2020;11:1223 pubmed 出版商
|
Erdel F, Rademacher A, Vlijm R, Tünnermann J, Frank L, Weinmann R, et al. Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation. Mol Cell. 2020;78:236-249.e7 pubmed 出版商
|
Hsu M, Liao H, Truong V, Huang K, Yu F, Chen H, et al. CRISPR-based Activation of Endogenous Neurotrophic Genes in Adipose Stem Cell Sheets to Stimulate Peripheral Nerve Regeneration. Theranostics. 2019;9:6099-6111 pubmed 出版商
|
Ritter N, Ali T, Kopitchinski N, Schuster P, Beisaw A, Hendrix D, et al. The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development. Dev Cell. 2019;50:644-657.e8 pubmed 出版商
|
Maji B, Gangopadhyay S, Lee M, Shi M, Wu P, Heler R, et al. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9. Cell. 2019;177:1067-1079.e19 pubmed 出版商
|
Yamazaki T, Fujikawa C, Kubota A, Takahashi A, Hirose T. CRISPRa-mediated NEAT1 lncRNA upregulation induces formation of intact paraspeckles. Biochem Biophys Res Commun. 2018;504:218-224 pubmed 出版商
|
Nakade S, Mochida K, Kunii A, Nakamae K, Aida T, Tanaka K, et al. Biased genome editing using the local accumulation of DSB repair molecules system. Nat Commun. 2018;9:3270 pubmed 出版商
|
Zhao Z, Sentürk N, Song C, Grummt I. lncRNA PAPAS tethered to the rDNA enhancer recruits hypophosphorylated CHD4/NuRD to repress rRNA synthesis at elevated temperatures. Genes Dev. 2018;32:836-848 pubmed 出版商
|
Chen C, Zeldich E, Li Y, Yuste A, Abraham C. Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex. J Mol Neurosci. 2018;64:175-184 pubmed 出版商
|
Lu J, Zhao C, Zhao Y, Zhang J, Zhang Y, Chen L, et al. Multimode drug inducible CRISPR/Cas9 devices for transcriptional activation and genome editing. Nucleic Acids Res. 2018;46:e25 pubmed 出版商
|
Liao H, Hatanaka F, Araoka T, Reddy P, Wu M, Sui Y, et al. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. Cell. 2017;171:1495-1507.e15 pubmed 出版商
|
Alexanian M, Maric D, Jenkinson S, Mina M, Friedman C, Ting C, et al. A transcribed enhancer dictates mesendoderm specification in pluripotency. Nat Commun. 2017;8:1806 pubmed 出版商
|
Ade C, Derbes R, Wagstaff B, Linker S, White T, Deharo D, et al. Evaluating different DNA binding domains to modulate L1 ORF2p-driven site-specific retrotransposition events in human cells. Gene. 2018;642:188-198 pubmed 出版商
|
Kleinjan D, Wardrope C, Nga Sou S, Rosser S. Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors. Nat Commun. 2017;8:1191 pubmed 出版商
|
Lundh M, Plucińska K, Isidor M, Petersen P, Emanuelli B. Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA. Mol Metab. 2017;6:1313-1320 pubmed 出版商
|
Kulcsár P, Tálas A, Huszár K, Ligeti Z, Tóth E, Weinhardt N, et al. Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage. Genome Biol. 2017;18:190 pubmed 出版商
|
Nihongaki Y, Furuhata Y, Otabe T, Hasegawa S, Yoshimoto K, Sato M. CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation. Nat Methods. 2017;14:963-966 pubmed 出版商
|
Micheletti R, Plaisance I, Abraham B, Sarre A, Ting C, Alexanian M, et al. The long noncoding RNA Wisper controls cardiac fibrosis and remodeling. Sci Transl Med. 2017;9: pubmed 出版商
|
Ferry Q, Lyutova R, Fulga T. Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs. Nat Commun. 2017;8:14633 pubmed 出版商
|
Hu L, Yu Y, Huang H, Fan H, Hu L, Yin C, et al. Epigenetic Regulation of Interleukin 6 by Histone Acetylation in Macrophages and Its Role in Paraquat-Induced Pulmonary Fibrosis. Front Immunol. 2016;7:696 pubmed 出版商
|
Chen F, Li X, Aquadro E, Haigh S, Zhou J, Stepp D, et al. Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension. Free Radic Biol Med. 2016;99:167-178 pubmed 出版商
|
Bialek J, Dunay G, Voges M, Schäfer C, Spohn M, Stucka R, et al. Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems. PLoS ONE. 2016;11:e0158294 pubmed 出版商
|
Fu Y, Rocha P, Luo V, Raviram R, Deng Y, Mazzoni E, et al. CRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual loci. Nat Commun. 2016;7:11707 pubmed 出版商
|
Kaczmarczyk L, Mende Y, Zevnik B, Jackson W. Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9. PLoS ONE. 2016;11:e0154604 pubmed 出版商
|
Konermann S, Brigham M, Trevino A, Joung J, Abudayyeh O, Bárcena C, et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature. 2015;517:583-8 pubmed 出版商
|