产品简要
公司名称 :
Abbexa
产品类型 :
抗体
产品名称 :
胰岛素受体(INSR)抗体
目录 :
abx034683
规格 :
80微升
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
产品信息
目录代码 :
abx034683
靶标 :
胰岛素受体(INSR)
产品名称 :
胰岛素受体(INSR)抗体
简称 :
INSR
Long Name :
胰岛素受体
类别 :
一抗
宿主 :
兔
克隆性 :
多克隆
共轭 :
未共轭
抗体亚型 :
IgG
规格1 :
80微升
规格2 :
400微升
产品描述 :
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol (3, 4, 5) triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
UniProt Primary AC :
P06213
UniProt数据库进入名 :
INSR_HUMAN
基因符号 :
INSR
OMIM :
125853
HGNC :
6091
KEGG :
hsa:3643
String :
9606.ENSP00000303830
纯化 :
Purified through a protein A column, followed by peptide affinity purification.
缓冲液 :
PBS含0.09% 叠氮化钠
检测过的应用 :
酶联免疫吸附测定, 免疫印迹
储存 :
分成小份儿保存在-20°C。 避免反复冻融
形式 :
液体
UNSPSC编码 :
12352203
Availability :
Shipped within 5-10 working days.
DryIce :
No
更多信息或购买 :
公司信息
![logo](http://aws.labome.com/img/2503.png)
Abbexa
Abbexa LTD, Cambridge, UK
Abbexa LLC, Houston, USA
Abbexa LLC, Houston, USA
info@abbexa.com
https://www.abbexa.com44 (0)1223 75595
1 832 327 7413
1 832 327 7413
公司总部: 英国
Abbexa is a biotechnology company based in Cambridge, UK, specializing in high quality, reliable research reagents for scientific research. We work in partnership with academic institutions, hospitals and laboratories across the world to bring an integrated source of antibodies, proteins, ELISA kits and other biological reagents. We are dedicated to providing excellent customer service, quality and affordable products to enable scientists to do better science. For more information, please visit http://www.abbexa.com/.